Polygenic hazard score, amyloid deposition and Alzheimer’s neurodegeneration

Mounting evidence indicates that the polygenic basis of late-onset Alzheimer’s disease can be harnessed to identify individuals at greatest risk for cognitive decline. We have previously developed and validated a polygenic hazard score comprising of 31 single nucleotide polymorphisms for predicting...

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Detalhes bibliográficos
Publicado no:Brain
Main Authors: Tan, Chin Hong, Bonham, Luke W, Fan, Chun Chieh, Mormino, Elizabeth C, Sugrue, Leo P, Broce, Iris J, Hess, Christopher P, Yokoyama, Jennifer S, Rabinovici, Gil D, Miller, Bruce L, Yaffe, Kristine, Schellenberg, Gerard D, Kauppi, Karolina, Holland, Dominic, McEvoy, Linda K, Kukull, Walter A, Tosun, Duygu, Weiner, Michael W, Sperling, Reisa A, Bennett, David A, Hyman, Bradley T, Andreassen, Ole A, Dale, Anders M, Desikan, Rahul S
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6351776/
https://ncbi.nlm.nih.gov/pubmed/30689776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awy327
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