Combining Polygenic Hazard Score With Volumetric MRI and Cognitive Measures Improves Prediction of Progression From Mild Cognitive Impairment to Alzheimer's Disease

Improved prediction of progression to Alzheimer's Disease (AD) among older individuals with mild cognitive impairment (MCI) is of high clinical and societal importance. We recently developed a polygenic hazard score (PHS) that predicted age of AD onset above and beyond APOE. Here, we used data...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Front Neurosci
Egile Nagusiak: Kauppi, Karolina, Fan, Chun Chieh, McEvoy, Linda K., Holland, Dominic, Tan, Chin Hong, Chen, Chi-Hua, Andreassen, Ole A., Desikan, Rahul S., Dale, Anders M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Frontiers Media S.A. 2018
Gaiak:
Neuroscience
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5937163/
https://ncbi.nlm.nih.gov/pubmed/29760643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2018.00260
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