Combining Polygenic Hazard Score With Volumetric MRI and Cognitive Measures Improves Prediction of Progression From Mild Cognitive Impairment to Alzheimer's Disease

Improved prediction of progression to Alzheimer's Disease (AD) among older individuals with mild cognitive impairment (MCI) is of high clinical and societal importance. We recently developed a polygenic hazard score (PHS) that predicted age of AD onset above and beyond APOE. Here, we used data...

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Hlavní autoři: Karolina Kauppi, Chun Chieh Fan, Linda K. McEvoy, Dominic Holland, Chin Hong Tan, Chi-Hua Chen, Ole A. Andreassen, Rahul S. Desikan, Anders M. Dale, The Alzheimer's Disease Neuroimaging Initiative
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018-04-01
Edice:Frontiers in Neuroscience
Témata:
pHs
MCI
AD prediction
MRI
genetics
On-line přístup:http://journal.frontiersin.org/article/10.3389/fnins.2018.00260/full
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