Beyond SNP heritability: Polygenicity and discoverability of phenotypes estimated with a univariate Gaussian mixture model

Estimating the polygenicity (proportion of causally associated single nucleotide polymorphisms (SNPs)) and discoverability (effect size variance) of causal SNPs for human traits is currently of considerable interest. SNP-heritability is proportional to the product of these quantities. We present a b...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Holland, Dominic, Frei, Oleksandr, Desikan, Rahul, Fan, Chun-Chieh, Shadrin, Alexey A., Smeland, Olav B., Sundar, V. S., Thompson, Paul, Andreassen, Ole A., Dale, Anders M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7272101/
https://ncbi.nlm.nih.gov/pubmed/32427991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008612
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