Beyond SNP heritability: Polygenicity and discoverability of phenotypes estimated with a univariate Gaussian mixture model

Estimating the polygenicity (proportion of causally associated single nucleotide polymorphisms (SNPs)) and discoverability (effect size variance) of causal SNPs for human traits is currently of considerable interest. SNP-heritability is proportional to the product of these quantities. We present a b...

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Xehetasun bibliografikoak
Argitaratua izan da:PLoS Genet
Egile Nagusiak: Holland, Dominic, Frei, Oleksandr, Desikan, Rahul, Fan, Chun-Chieh, Shadrin, Alexey A., Smeland, Olav B., Sundar, V. S., Thompson, Paul, Andreassen, Ole A., Dale, Anders M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2020
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7272101/
https://ncbi.nlm.nih.gov/pubmed/32427991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008612
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