Beyond SNP heritability: Polygenicity and discoverability of phenotypes estimated with a univariate Gaussian mixture model

Estimating the polygenicity (proportion of causally associated single nucleotide polymorphisms (SNPs)) and discoverability (effect size variance) of causal SNPs for human traits is currently of considerable interest. SNP-heritability is proportional to the product of these quantities. We present a b...

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Опубликовано в: :PLoS Genet
Главные авторы: Holland, Dominic, Frei, Oleksandr, Desikan, Rahul, Fan, Chun-Chieh, Shadrin, Alexey A., Smeland, Olav B., Sundar, V. S., Thompson, Paul, Andreassen, Ole A., Dale, Anders M.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2020
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7272101/
https://ncbi.nlm.nih.gov/pubmed/32427991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008612
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