The genetic architecture of human complex phenotypes is modulated by linkage disequilibrium and heterozygosity

We propose an extended Gaussian mixture model for the distribution of causal effects of common single nucleotide polymorphisms (SNPs) for human complex phenotypes that depends on linkage disequilibrium (LD) and heterozygosity (H), while also allowing for independent components for small and large ef...

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Publicat a:Genetics
Autors principals: Holland, Dominic, Frei, Oleksandr, Desikan, Rahul, Fan, Chun-Chieh, Shadrin, Alexey A, Smeland, Olav B, Andreassen, Ole A, Dale, Anders M
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2021
Matèries:
Investigation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8045737/
https://ncbi.nlm.nih.gov/pubmed/33789345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/genetics/iyaa046
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