Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation

Accumulating evidence from genome wide association studies (GWAS) suggests an abundance of shared genetic influences among complex human traits and disorders, such as mental disorders. Here we introduce a statistical tool, MiXeR, which quantifies polygenic overlap irrespective of genetic correlation...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Frei, Oleksandr, Holland, Dominic, Smeland, Olav B., Shadrin, Alexey A., Fan, Chun Chieh, Maeland, Steffen, O’Connell, Kevin S., Wang, Yunpeng, Djurovic, Srdjan, Thompson, Wesley K., Andreassen, Ole A., Dale, Anders M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6547727/
https://ncbi.nlm.nih.gov/pubmed/31160569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10310-0
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados