The genetic architecture of human complex phenotypes is modulated by linkage disequilibrium and heterozygosity

We propose an extended Gaussian mixture model for the distribution of causal effects of common single nucleotide polymorphisms (SNPs) for human complex phenotypes that depends on linkage disequilibrium (LD) and heterozygosity (H), while also allowing for independent components for small and large ef...

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Detalhes bibliográficos
Publicado no:Genetics
Main Authors: Holland, Dominic, Frei, Oleksandr, Desikan, Rahul, Fan, Chun-Chieh, Shadrin, Alexey A, Smeland, Olav B, Andreassen, Ole A, Dale, Anders M
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2021
Assuntos:
Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8045737/
https://ncbi.nlm.nih.gov/pubmed/33789345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/genetics/iyaa046
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