Polygenic hazard score: an enrichment marker for Alzheimer’s associated amyloid and tau deposition

There is an urgent need for identifying nondemented individuals at the highest risk of progressing to Alzheimer’s disease (AD) dementia. Here, we evaluated whether a recently validated polygenic hazard score (PHS) can be integrated with known in vivo cerebrospinal fluid (CSF) or positron emission to...

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Publicado en:Acta Neuropathol
Main Authors: Tan, Chin Hong, Fan, Chun Chieh, Mormino, Elizabeth C., Sugrue, Leo P., Broce, Iris J., Hess, Christopher P., Dillon, William P., Bonham, Luke W., Yokoyama, Jennifer S., Karch, Celeste M., Brewer, James B., Rabinovici, Gil D., Miller, Bruce L., Schellenberg, Gerard D., Kauppi, Karolina, Feldman, Howard A., Holland, Dominic, McEvoy, Linda K., Hyman, Bradley T., Bennett, David A., Andreassen, Ole A., Dale, Anders M., Desikan, Rahul S.
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5758038/
https://ncbi.nlm.nih.gov/pubmed/29177679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-017-1789-4
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