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Using Homology Modeling to Interrogate Binding Affinity in Neutralization of Ricin Toxin by a Family of Single Domain Antibodies
In this report we investigated, within a group of closely related single domain camelid antibodies (V(H)Hs), the relationship between binding affinity and neutralizing activity as it pertains to ricin, a fast-acting toxin and biothreat agent. The V1C7-like V(H)Hs (V1C7, V2B9, V2E8, and V5C1) are sim...
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| Publicado no: | Proteins |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5754017/ https://ncbi.nlm.nih.gov/pubmed/28718923 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.25353 |
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