Contribution of an unusual CDR2 element of a single domain antibody in ricin toxin binding affinity and neutralizing activity

Ricin toxin’s enzymatic subunit (RTA) has been subjected to intensive B cell epitope mapping studies using a combination of competition ELISAs, hydrogen exchange-mass spectrometry and X-ray crystallography. Those studies identified four spatially distinct clusters (I–IV) of toxin-neutralizing epitop...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Protein Eng Des Sel
Main Authors: Rudolph, Michael J, Vance, David J, Kelow, Simon, Angalakurthi, Siva Krishna, Nguyen, Sophie, Davis, Simon A, Rong, Yinghui, Middaugh, C Russell, Weis, David D, Dunbrack, Roland, Karanicolas, John, Mantis, Nicholas J
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6277176/
https://ncbi.nlm.nih.gov/pubmed/30265352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzy022
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados