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Contribution of an unusual CDR2 element of a single domain antibody in ricin toxin binding affinity and neutralizing activity
Ricin toxin’s enzymatic subunit (RTA) has been subjected to intensive B cell epitope mapping studies using a combination of competition ELISAs, hydrogen exchange-mass spectrometry and X-ray crystallography. Those studies identified four spatially distinct clusters (I–IV) of toxin-neutralizing epitop...
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| 發表在: | Protein Eng Des Sel |
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| Main Authors: | , , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Oxford University Press
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6277176/ https://ncbi.nlm.nih.gov/pubmed/30265352 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzy022 |
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