Mutant Cullin 3 causes familial hyperkalemic hypertension via dominant effects

Mutations in the ubiquitin ligase scaffold protein Cullin 3 (CUL3) cause the disease familial hyperkalemic hypertension (FHHt). In the kidney, mutant CUL3 (CUL3-Δ9) increases abundance of With-No-Lysine [K] Kinase 4 (WNK4), with excessive activation of the downstream Sterile 20 (STE20)/SPS-1–related...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:JCI Insight
Egile Nagusiak: Ferdaus, Mohammed Z., Miller, Lauren N., Agbor, Larry N., Saritas, Turgay, Singer, Jeffrey D., Sigmund, Curt D., McCormick, James A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2017
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752287/
https://ncbi.nlm.nih.gov/pubmed/29263298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.96700
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