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Conditional deletion of smooth muscle Cullin-3 causes severe progressive hypertension
Patients with mutations in Cullin-3 (CUL3) exhibit severe early-onset hypertension, but the contribution of the smooth muscle remains unclear. Conditional genetic ablation of CUL3 in vascular smooth muscle (S-CUL3KO) causes progressive impairment in response to NO, rapid development of severe hypert...
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| Gepubliceerd in: | JCI Insight |
|---|---|
| Hoofdauteurs: | , , , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Society for Clinical Investigation
2019
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6675584/ https://ncbi.nlm.nih.gov/pubmed/31184598 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.129793 |
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