Conditional deletion of smooth muscle Cullin-3 causes severe progressive hypertension

Patients with mutations in Cullin-3 (CUL3) exhibit severe early-onset hypertension, but the contribution of the smooth muscle remains unclear. Conditional genetic ablation of CUL3 in vascular smooth muscle (S-CUL3KO) causes progressive impairment in response to NO, rapid development of severe hypert...

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Publicat a:JCI Insight
Autors principals: Agbor, Larry N., Nair, Anand R., Wu, Jing, Lu, Ko-Ting, Davis, Deborah R., Keen, Henry L., Quelle, Frederick W., McCormick, James A., Singer, Jeffrey D., Sigmund, Curt D.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6675584/
https://ncbi.nlm.nih.gov/pubmed/31184598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.129793
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