RhoBTB1 protects against hypertension and arterial stiffness by restraining phosphodiesterase 5 activity

Mice selectively expressing a PPARγ dominant-negative mutation in vascular smooth muscle exhibit RhoBTB1 deficiency and hypertension. Our rationale was to use genetic complementation to uncover the mechanism of action of RhoBTB1 in vascular smooth muscle. Inducible smooth muscle–specific restoration...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Clin Invest
Main Authors: Mukohda, Masashi, Fang, Shi, Wu, Jing, Agbor, Larry N., Nair, Anand R., Ibeawuchi, Stella-Rita C., Hu, Chunyan, Liu, Xuebo, Lu, Ko-Ting, Guo, Deng-Fu, Davis, Deborah R., Keen, Henry L., Quelle, Frederick W., Sigmund, Curt D.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2019
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6546477/
https://ncbi.nlm.nih.gov/pubmed/30896450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI123462
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