RhoBTB1 protects against hypertension and arterial stiffness by restraining phosphodiesterase 5 activity

Mice selectively expressing a PPARγ dominant-negative mutation in vascular smooth muscle exhibit RhoBTB1 deficiency and hypertension. Our rationale was to use genetic complementation to uncover the mechanism of action of RhoBTB1 in vascular smooth muscle. Inducible smooth muscle–specific restoration...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Mukohda, Masashi, Fang, Shi, Wu, Jing, Agbor, Larry N., Nair, Anand R., Ibeawuchi, Stella-Rita C., Hu, Chunyan, Liu, Xuebo, Lu, Ko-Ting, Guo, Deng-Fu, Davis, Deborah R., Keen, Henry L., Quelle, Frederick W., Sigmund, Curt D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6546477/
https://ncbi.nlm.nih.gov/pubmed/30896450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI123462
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