RhoBTB1 protects against hypertension and arterial stiffness by restraining phosphodiesterase 5 activity

Mice selectively expressing a PPARγ dominant-negative mutation in vascular smooth muscle exhibit RhoBTB1 deficiency and hypertension. Our rationale was to use genetic complementation to uncover the mechanism of action of RhoBTB1 in vascular smooth muscle. Inducible smooth muscle–specific restoration...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Clin Invest
Prif Awduron: Mukohda, Masashi, Fang, Shi, Wu, Jing, Agbor, Larry N., Nair, Anand R., Ibeawuchi, Stella-Rita C., Hu, Chunyan, Liu, Xuebo, Lu, Ko-Ting, Guo, Deng-Fu, Davis, Deborah R., Keen, Henry L., Quelle, Frederick W., Sigmund, Curt D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2019
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6546477/
https://ncbi.nlm.nih.gov/pubmed/30896450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI123462
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