RhoBTB1 protects against hypertension and arterial stiffness by restraining phosphodiesterase 5 activity

Mice selectively expressing a PPARγ dominant-negative mutation in vascular smooth muscle exhibit RhoBTB1 deficiency and hypertension. Our rationale was to use genetic complementation to uncover the mechanism of action of RhoBTB1 in vascular smooth muscle. Inducible smooth muscle–specific restoration...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Clin Invest
Egile Nagusiak: Mukohda, Masashi, Fang, Shi, Wu, Jing, Agbor, Larry N., Nair, Anand R., Ibeawuchi, Stella-Rita C., Hu, Chunyan, Liu, Xuebo, Lu, Ko-Ting, Guo, Deng-Fu, Davis, Deborah R., Keen, Henry L., Quelle, Frederick W., Sigmund, Curt D.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2019
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6546477/
https://ncbi.nlm.nih.gov/pubmed/30896450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI123462
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