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RhoBTB1 protects against hypertension and arterial stiffness by restraining phosphodiesterase 5 activity
Mice selectively expressing a PPARγ dominant-negative mutation in vascular smooth muscle exhibit RhoBTB1 deficiency and hypertension. Our rationale was to use genetic complementation to uncover the mechanism of action of RhoBTB1 in vascular smooth muscle. Inducible smooth muscle–specific restoration...
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| Veröffentlicht in: | J Clin Invest |
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| Hauptverfasser: | , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Clinical Investigation
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6546477/ https://ncbi.nlm.nih.gov/pubmed/30896450 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI123462 |
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