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Mutant Cullin 3 causes familial hyperkalemic hypertension via dominant effects
Mutations in the ubiquitin ligase scaffold protein Cullin 3 (CUL3) cause the disease familial hyperkalemic hypertension (FHHt). In the kidney, mutant CUL3 (CUL3-Δ9) increases abundance of With-No-Lysine [K] Kinase 4 (WNK4), with excessive activation of the downstream Sterile 20 (STE20)/SPS-1–related...
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| Publicado no: | JCI Insight |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5752287/ https://ncbi.nlm.nih.gov/pubmed/29263298 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.96700 |
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