Mutant Cullin 3 causes familial hyperkalemic hypertension via dominant effects

Mutations in the ubiquitin ligase scaffold protein Cullin 3 (CUL3) cause the disease familial hyperkalemic hypertension (FHHt). In the kidney, mutant CUL3 (CUL3-Δ9) increases abundance of With-No-Lysine [K] Kinase 4 (WNK4), with excessive activation of the downstream Sterile 20 (STE20)/SPS-1–related...

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Udgivet i:JCI Insight
Main Authors: Ferdaus, Mohammed Z., Miller, Lauren N., Agbor, Larry N., Saritas, Turgay, Singer, Jeffrey D., Sigmund, Curt D., McCormick, James A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752287/
https://ncbi.nlm.nih.gov/pubmed/29263298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.96700
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