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Mechanisms and controversies in mutant Cul3-mediated familial hyperkalemic hypertension
Autosomal dominant mutations in cullin-3 (Cul3) cause the most severe form of familial hyperkalemic hypertension (FHHt). Cul3 mutations cause skipping of exon 9, which results in an internal deletion of 57 amino acids from the CUL3 protein (CUL3-∆9). The precise mechanism by which this altered form...
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| Publicado no: | Am J Physiol Renal Physiol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6031903/ https://ncbi.nlm.nih.gov/pubmed/29361671 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00593.2017 |
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