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Hypertension-causing Mutations in Cullin3 Protein Impair RhoA Protein Ubiquitination and Augment the Association with Substrate Adaptors

Cullin-Ring ubiquitin ligases regulate protein turnover by promoting the ubiquitination of substrate proteins, targeting them for proteasomal degradation. It has been shown previously that mutations in Cullin3 (Cul3) causing deletion of 57 amino acids encoded by exon 9 (Cul3Δ9) cause hypertension. M...

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Foilsithe in:J Biol Chem
Main Authors: Ibeawuchi, Stella-Rita C., Agbor, Larry N., Quelle, Frederick W., Sigmund, Curt D.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2015
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4521042/
https://ncbi.nlm.nih.gov/pubmed/26100637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.645358
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