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Structure‐Guided Design of Peptides as Tools to Probe the Protein–Protein Interaction between Cullin‐2 and Elongin BC Substrate Adaptor in Cullin RING E3 Ubiquitin Ligases

Cullin RING E3 ubiquitin ligases (CRLs) are large dynamic multi‐subunit complexes that control the fate of many proteins in cells. CRLs are attractive drug targets for the development of small‐molecule inhibitors and chemical inducers of protein degradation. Herein we describe a structure‐guided bio...

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Detalhes bibliográficos
Publicado no:ChemMedChem
Main Authors: Cardote, Teresa A. F., Ciulli, Alessio
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5639367/
https://ncbi.nlm.nih.gov/pubmed/28776949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201700359
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