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The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses
Death-associated protein kinase (DAPK) was identified as a mediator of interferon (IFN)-induced cell death. How IFN controls DAPK activation remains largely unknown. Here, we identify the BTB–Kelch protein KLHL20 as a negative regulator of DAPK. KLHL20 binds DAPK and Cullin 3 (Cul3) via its Kelch-re...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2876967/ https://ncbi.nlm.nih.gov/pubmed/20389280 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.62 |
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