Hyperkalemic hypertension–associated cullin 3 promotes WNK signaling by degrading KLHL3

Familial hyperkalemic hypertension (FHHt) is a monogenic disease resulting from mutations in genes encoding WNK kinases, the ubiquitin scaffold protein cullin 3 (CUL3), or the substrate adaptor kelch-like 3 (KLHL3). Disease-associated CUL3 mutations abrogate WNK kinase degradation in cells, but it i...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: McCormick, James A., Yang, Chao-Ling, Zhang, Chong, Davidge, Brittney, Blankenstein, Katharina I., Terker, Andrew S., Yarbrough, Bethzaida, Meermeier, Nicholas P., Park, Hae J., McCully, Belinda, West, Mark, Borschewski, Aljona, Himmerkus, Nina, Bleich, Markus, Bachmann, Sebastian, Mutig, Kerim, Argaiz, Eduardo R., Gamba, Gerardo, Singer, Jeffrey D., Ellison, David H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4347254/
https://ncbi.nlm.nih.gov/pubmed/25250572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI76126
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