Hyperkalemic hypertension–associated cullin 3 promotes WNK signaling by degrading KLHL3

Familial hyperkalemic hypertension (FHHt) is a monogenic disease resulting from mutations in genes encoding WNK kinases, the ubiquitin scaffold protein cullin 3 (CUL3), or the substrate adaptor kelch-like 3 (KLHL3). Disease-associated CUL3 mutations abrogate WNK kinase degradation in cells, but it i...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:J Clin Invest
Autori principali: McCormick, James A., Yang, Chao-Ling, Zhang, Chong, Davidge, Brittney, Blankenstein, Katharina I., Terker, Andrew S., Yarbrough, Bethzaida, Meermeier, Nicholas P., Park, Hae J., McCully, Belinda, West, Mark, Borschewski, Aljona, Himmerkus, Nina, Bleich, Markus, Bachmann, Sebastian, Mutig, Kerim, Argaiz, Eduardo R., Gamba, Gerardo, Singer, Jeffrey D., Ellison, David H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2014
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4347254/
https://ncbi.nlm.nih.gov/pubmed/25250572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI76126
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi