Degradation by Cullin3 and effect on WNK kinases suggest a role of KLHL2 in the pathogenesis of Familial Hyperkalemic Hypertension

Mutations in WNK1 and WNK4, and in components of the Cullin-Ring Ligase system, kelch-like 3 (KLHL3) and Cullin3 (CUL3), can cause the rare hereditary disease, Familial Hyperkalemic Hypertension (FHHt). The disease is characterized by overactivity of the renal sodium chloride cotransporter (NCC), wh...

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Udgivet i:Biochem Biophys Res Commun
Main Authors: Zhang, Chong, Meermeier, Nicholas P., Terker, Andrew S., Blankenstein, Katharina I., Singer, Jeffrey D., Hadchouel, Juliette, Ellison, David H., Yang, Chao-Ling
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4695252/
https://ncbi.nlm.nih.gov/pubmed/26607111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2015.11.067
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