Hyperkalemic hypertension–associated cullin 3 promotes WNK signaling by degrading KLHL3

Familial hyperkalemic hypertension (FHHt) is a monogenic disease resulting from mutations in genes encoding WNK kinases, the ubiquitin scaffold protein cullin 3 (CUL3), or the substrate adaptor kelch-like 3 (KLHL3). Disease-associated CUL3 mutations abrogate WNK kinase degradation in cells, but it i...

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Bibliografski detalji
Izdano u:J Clin Invest
Glavni autori: McCormick, James A., Yang, Chao-Ling, Zhang, Chong, Davidge, Brittney, Blankenstein, Katharina I., Terker, Andrew S., Yarbrough, Bethzaida, Meermeier, Nicholas P., Park, Hae J., McCully, Belinda, West, Mark, Borschewski, Aljona, Himmerkus, Nina, Bleich, Markus, Bachmann, Sebastian, Mutig, Kerim, Argaiz, Eduardo R., Gamba, Gerardo, Singer, Jeffrey D., Ellison, David H.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2014
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4347254/
https://ncbi.nlm.nih.gov/pubmed/25250572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI76126
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