SOX6 Downregulation Induces γ-Globin in Human β-Thalassemia Major Erythroid Cells

BACKGROUND: Fetal hemoglobin (HbF; α(2)γ(2)) is a potent genetic modifier of the severity of β-thalassemia and sickle cell anemia. Differences in the levels of HbF that persist into adulthood affect the severity of sickle cell disease and the β-thalassemia syndromes. Sry type HMG box (SOX6) is a pot...

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Detalhes bibliográficos
Publicado no:Biomed Res Int
Main Authors: Li, Jing, Lai, Yongrong, Luo, Jun, Luo, Lin, Liu, Rongrong, Liu, Zhenfang, Zhao, Weihua
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2017
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5733236/
https://ncbi.nlm.nih.gov/pubmed/29333458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/9496058
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