Epigenetic inactivation of ERF reactivates γ-globin expression in β-thalassemia

The fetal-to-adult hemoglobin switch is regulated in a developmental stage-specific manner and reactivation of fetal hemoglobin (HbF) has therapeutic implications for treatment of β-thalassemia and sickle cell anemia, two major global health problems. Although significant progress has been made in o...

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Pubblicato in:Am J Hum Genet
Autori principali: Bao, Xiuqin, Zhang, Xinhua, Wang, Liren, Wang, Zhongju, Huang, Jin, Zhang, Qianqian, Ye, Yuhua, Liu, Yongqiong, Chen, Diyu, Zuo, Yangjin, Liu, Qifa, Xu, Peng, Huang, Binbin, Fang, Jianpei, Lao, Jinquan, Feng, Xiaoqin, Li, Yafeng, Kurita, Ryo, Nakamura, Yukio, Yu, Weiwei, Ju, Cunxiang, Huang, Chunbo, Mohandas, Narla, Li, Dali, Zhao, Cunyou, Xu, Xiangmin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8059375/
https://ncbi.nlm.nih.gov/pubmed/33735615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2021.03.005
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