Epigenetic inactivation of ERF reactivates γ-globin expression in β-thalassemia

The fetal-to-adult hemoglobin switch is regulated in a developmental stage-specific manner and reactivation of fetal hemoglobin (HbF) has therapeutic implications for treatment of β-thalassemia and sickle cell anemia, two major global health problems. Although significant progress has been made in o...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Am J Hum Genet
Hauptverfasser: Bao, Xiuqin, Zhang, Xinhua, Wang, Liren, Wang, Zhongju, Huang, Jin, Zhang, Qianqian, Ye, Yuhua, Liu, Yongqiong, Chen, Diyu, Zuo, Yangjin, Liu, Qifa, Xu, Peng, Huang, Binbin, Fang, Jianpei, Lao, Jinquan, Feng, Xiaoqin, Li, Yafeng, Kurita, Ryo, Nakamura, Yukio, Yu, Weiwei, Ju, Cunxiang, Huang, Chunbo, Mohandas, Narla, Li, Dali, Zhao, Cunyou, Xu, Xiangmin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2021
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8059375/
https://ncbi.nlm.nih.gov/pubmed/33735615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2021.03.005
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge