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DNA methylation patterns of β-globin cluster in β-thalassemia patients
BACKGROUND: Reactivation of fetal hemoglobin (HbF, α(2)γ(2)) holds a therapeutic target for β-thalassemia and sickle cell disease. Although many HbF regulators have been identified, the methylation patterns in β-globin cluster driving the fetal-to-adult hemoglobin switch remains to be determined. RE...
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| Pubblicato in: | Clin Epigenetics |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BioMed Central
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7712619/ https://ncbi.nlm.nih.gov/pubmed/33272312 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-020-00987-2 |
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