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SOX6 Downregulation Induces γ-Globin in Human β-Thalassemia Major Erythroid Cells
BACKGROUND: Fetal hemoglobin (HbF; α(2)γ(2)) is a potent genetic modifier of the severity of β-thalassemia and sickle cell anemia. Differences in the levels of HbF that persist into adulthood affect the severity of sickle cell disease and the β-thalassemia syndromes. Sry type HMG box (SOX6) is a pot...
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| Izdano u: | Biomed Res Int |
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| Glavni autori: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Hindawi
2017
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5733236/ https://ncbi.nlm.nih.gov/pubmed/29333458 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/9496058 |
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