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Understanding globin regulation in β-thalassemia: it’s as simple as α, β, γ, δ
A vast excess of α-globin production and inadequate γ-globin compensation lead to the development of severe anemia in human β-thalassemia. Newly identified modifiers of α- and γ-globin synthesis and insights into the mechanisms of globin regulation provide the tools for potential new approaches to t...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2005
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1137010/ https://ncbi.nlm.nih.gov/pubmed/15931385 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI25398 |
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