Reciprocal regulation of γ-globin expression by exo-miRNAs: Relevance to γ-globin silencing in β-thalassemia major

Induction of fetal hemoglobin (HbF) is a promising strategy in the treatment of β-thalassemia major (β-TM). The present study shows that plasma exosomal miRNAs (exo-miRs) are involved in γ-globin regulation. Exosomes shuttle miRNAs and mediate cell-cell communication. MiRNAs are regulators of biolog...

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Publicado no:Sci Rep
Principais autores: Sun, Kuo-Ting, Huang, Yu-Nan, Palanisamy, Kalaiselvi, Chang, Shih-Sheng, Wang, I-Kuan, Wu, Kang-Hsi, Chen, Ping, Peng, Ching-Tien, Li, Chi-Yuan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5427890/
https://ncbi.nlm.nih.gov/pubmed/28303002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-00150-7
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