HDAC8 regulates long-term hematopoietic stem-cell maintenance under stress by modulating p53 activity

The maintenance and functional integrity of long-term hematopoietic stem cells (LT-HSCs) is critical for lifelong hematopoietic regeneration. Histone deacetylases (HDACs) modulate acetylation of lysine residues, a protein modification important for regulation of numerous biological processes. Here,...

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Udgivet i:Blood
Main Authors: Hua, Wei-Kai, Qi, Jing, Cai, Qi, Carnahan, Emily, Ayala Ramirez, Maria, Li, Ling, Marcucci, Guido, Kuo, Ya-Huei
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2017
Fag:
Hematopoiesis and Stem Cells
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5731083/
https://ncbi.nlm.nih.gov/pubmed/29084772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-03-771386
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