HDAC8 Inhibition Specifically Targets Inv(16) Acute Myeloid Leukemic Stem Cells by Restoring p53 Acetylation

Acute myeloid leukemia (AML) is driven and sustained by leukemia stem cells (LSCs) with unlimited self-renewal capacity and resistance to chemotherapy. Mutation in the TP53 tumor suppressor is relatively rare in de novo AML; however, p53 can be regulated through post-translational mechanisms. Here,...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Cell Stem Cell
Asıl Yazarlar: Qi, Jing, Singh, Sandeep, Hua, Wei-Kai, Cai, Qi, Chao, Shi-Wei, Li, Ling, Liu, Hongjun, Ho, Yinwei, McDonald, Tinisha, Lin, Allen, Marcucci, Guido, Bhatia, Ravi, Huang, Wei-Jan, Chang, Chung-I, Kuo, Ya-Huei
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4636961/
https://ncbi.nlm.nih.gov/pubmed/26387755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2015.08.004
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller