The Src and c-Kit kinase inhibitor dasatinib enhances p53-mediated targeting of human acute myeloid leukemia stem cells by chemotherapeutic agents

The SRC family kinases (SFKs) and the receptor tyrosine kinase c-Kit are activated in human acute myeloid leukemia (AML) cells. We show here that the SFKs LYN, HCK, or FGR are overexpressed and activated in AML progenitor cells. Treatment with the SFK and c-KIT inhibitor dasatinib selectively inhibi...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Dos Santos, Cedric, McDonald, Tinisha, Ho, Yin Wei, Liu, Hongjun, Lin, Allen, Forman, Stephen J., Kuo, Ya-Huei, Bhatia, Ravi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4968345/
https://ncbi.nlm.nih.gov/pubmed/23896410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-11-466425
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