Autophagy is dispensable for the maintenance of hematopoietic stem cells in neonates

Hematopoietic stem cells (HSCs) undergo self-renewal or differentiation to sustain lifelong hematopoiesis. HSCs are preserved in quiescence with low mitochondrial activity. Recent studies indicate that autophagy contributes to HSC quiescence through suppressing mitochondrial metabolism. However, it...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Hashimoto, Michihiro, Umemoto, Terumasa, Nakamura-Ishizu, Ayako, Matsumura, Takayoshi, Yokomizo, Tomomasa, Sezaki, Maiko, Takizawa, Hitoshi, Suda, Toshio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2021
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7993101/
https://ncbi.nlm.nih.gov/pubmed/33710340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020002410
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