Lysine acetyltransferase Tip60 is required for hematopoietic stem cell maintenance

Hematopoietic stem cells (HSCs) have the potential to replenish the blood system for the lifetime of the organism. Their 2 defining properties, self-renewal and differentiation, are tightly regulated by the epigenetic machineries. Using conditional gene-knockout models, we demonstrated a critical re...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Numata, Akihiko, Kwok, Hui Si, Zhou, Qi-Ling, Li, Jia, Tirado-Magallanes, Roberto, Angarica, Vladimir Espinosa, Hannah, Rebecca, Park, Jihye, Wang, Chelsia Qiuxia, Krishnan, Vaidehi, Rajagopalan, Deepa, Zhang, Yanzhou, Zhou, Siqin, Welner, Robert S., Osato, Motomi, Jha, Sudhakar, Bohlander, Stefan K., Göttgens, Berthold, Yang, Henry, Benoukraf, Touati, Lough, John W., Bararia, Deepak, Tenen, Daniel G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7544546/
https://ncbi.nlm.nih.gov/pubmed/32542325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019001279
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