Lysine acetyltransferase Tip60 is required for hematopoietic stem cell maintenance

Hematopoietic stem cells (HSCs) have the potential to replenish the blood system for the lifetime of the organism. Their 2 defining properties, self-renewal and differentiation, are tightly regulated by the epigenetic machineries. Using conditional gene-knockout models, we demonstrated a critical re...

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Pubblicato in:Blood
Autori principali: Numata, Akihiko, Kwok, Hui Si, Zhou, Qi-Ling, Li, Jia, Tirado-Magallanes, Roberto, Angarica, Vladimir Espinosa, Hannah, Rebecca, Park, Jihye, Wang, Chelsia Qiuxia, Krishnan, Vaidehi, Rajagopalan, Deepa, Zhang, Yanzhou, Zhou, Siqin, Welner, Robert S., Osato, Motomi, Jha, Sudhakar, Bohlander, Stefan K., Göttgens, Berthold, Yang, Henry, Benoukraf, Touati, Lough, John W., Bararia, Deepak, Tenen, Daniel G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2020
Soggetti:
Hematopoiesis and Stem Cells
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7544546/
https://ncbi.nlm.nih.gov/pubmed/32542325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019001279
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