Lysine acetyltransferase Tip60 is required for hematopoietic stem cell maintenance

Hematopoietic stem cells (HSCs) have the potential to replenish the blood system for the lifetime of the organism. Their 2 defining properties, self-renewal and differentiation, are tightly regulated by the epigenetic machineries. Using conditional gene-knockout models, we demonstrated a critical re...

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Bibliografiska uppgifter
I publikationen:Blood
Huvudupphovsmän: Numata, Akihiko, Kwok, Hui Si, Zhou, Qi-Ling, Li, Jia, Tirado-Magallanes, Roberto, Angarica, Vladimir Espinosa, Hannah, Rebecca, Park, Jihye, Wang, Chelsia Qiuxia, Krishnan, Vaidehi, Rajagopalan, Deepa, Zhang, Yanzhou, Zhou, Siqin, Welner, Robert S., Osato, Motomi, Jha, Sudhakar, Bohlander, Stefan K., Göttgens, Berthold, Yang, Henry, Benoukraf, Touati, Lough, John W., Bararia, Deepak, Tenen, Daniel G.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Hematology 2020
Ämnen:
Hematopoiesis and Stem Cells
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7544546/
https://ncbi.nlm.nih.gov/pubmed/32542325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019001279
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