Structure, Immunogenicity, and Protective Mechanism of an Engineered Enterovirus 71-Like Particle Vaccine Mimicking 80S Empty Capsid

Enterovirus 71 (EV71) is the major causative agent of severe hand, foot, and mouth disease, which affects millions of young children in the Asia-Pacific region annually. In this study, we engineered a novel EV71 virus-like particle (VLP) that lacks VP4 (therefore designated VLP(ΔVP4)) and investigat...

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Bibliografiske detaljer
Udgivet i:J Virol
Main Authors: Wang, Xiaoli, Ku, Zhiqiang, Zhang, Xiang, Ye, Xiaohua, Chen, Jinhuan, Liu, Qingwei, Zhang, Wei, Zhang, Chao, Fu, Zhenglin, Jin, Xia, Cong, Yao, Huang, Zhong
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2017
Fag:
Vaccines and Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5730765/
https://ncbi.nlm.nih.gov/pubmed/29070691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01330-17
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