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Single Neutralizing Monoclonal Antibodies Targeting the VP1 GH Loop of Enterovirus 71 Inhibit both Virus Attachment and Internalization during Viral Entry

Antibodies play a critical role in immunity against enterovirus 71 (EV71). However, how EV71-specific antibodies neutralize infections remains poorly understood. Here we report the working mechanism for a group of three monoclonal antibodies (MAbs) that potently neutralize EV71. We found that these...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Ku, Zhiqiang, Ye, Xiaohua, Shi, Jinping, Wang, Xiaoli, Liu, Qingwei, Huang, Zhong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4645313/
https://ncbi.nlm.nih.gov/pubmed/26401034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02189-15
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