The Capsid Binder Vapendavir and the Novel Protease Inhibitor SG85 Inhibit Enterovirus 71 Replication

Antivirals against enterovirus 71 (EV71) are urgently needed. We demonstrate that the novel enteroviral protease inhibitor (PI) SG85 and capsid binder (CB) vapendavir efficiently inhibit the in vitro replication of 21 EV71 strains/isolates that are representative of the different genogroups A, B, an...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Tijsma, Aloys, Franco, David, Tucker, Simon, Hilgenfeld, Rolf, Froeyen, Mathy, Leyssen, Pieter, Neyts, Johan
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249361/
https://ncbi.nlm.nih.gov/pubmed/25199773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03328-14
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