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The Capsid Binder Vapendavir and the Novel Protease Inhibitor SG85 Inhibit Enterovirus 71 Replication

Antivirals against enterovirus 71 (EV71) are urgently needed. We demonstrate that the novel enteroviral protease inhibitor (PI) SG85 and capsid binder (CB) vapendavir efficiently inhibit the in vitro replication of 21 EV71 strains/isolates that are representative of the different genogroups A, B, an...

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Détails bibliographiques
Publié dans:Antimicrob Agents Chemother
Auteurs principaux: Tijsma, Aloys, Franco, David, Tucker, Simon, Hilgenfeld, Rolf, Froeyen, Mathy, Leyssen, Pieter, Neyts, Johan
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2014
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249361/
https://ncbi.nlm.nih.gov/pubmed/25199773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03328-14
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