Structure Elucidation of Coxsackievirus A16 in Complex with GPP3 Informs a Systematic Review of Highly Potent Capsid Binders to Enteroviruses

The replication of enterovirus 71 (EV71) and coxsackievirus A16 (CVA16), which are the major cause of hand, foot and mouth disease (HFMD) in children, can be inhibited by the capsid binder GPP3. Here, we present the crystal structure of CVA16 in complex with GPP3, which clarifies the role of the key...

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Bibliographic Details
Published in:PLoS Pathog
Main Authors: De Colibus, Luigi, Wang, Xiangxi, Tijsma, Aloys, Neyts, Johan, Spyrou, John A. B., Ren, Jingshan, Grimes, Jonathan M., Puerstinger, Gerhard, Leyssen, Pieter, Fry, Elizabeth E., Rao, Zihe, Stuart, David I.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4613828/
https://ncbi.nlm.nih.gov/pubmed/26485389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005165
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