Structure Elucidation of Coxsackievirus A16 in Complex with GPP3 Informs a Systematic Review of Highly Potent Capsid Binders to Enteroviruses

The replication of enterovirus 71 (EV71) and coxsackievirus A16 (CVA16), which are the major cause of hand, foot and mouth disease (HFMD) in children, can be inhibited by the capsid binder GPP3. Here, we present the crystal structure of CVA16 in complex with GPP3, which clarifies the role of the key...

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Publicat a:PLoS Pathog
Autors principals: De Colibus, Luigi, Wang, Xiangxi, Tijsma, Aloys, Neyts, Johan, Spyrou, John A. B., Ren, Jingshan, Grimes, Jonathan M., Puerstinger, Gerhard, Leyssen, Pieter, Fry, Elizabeth E., Rao, Zihe, Stuart, David I.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4613828/
https://ncbi.nlm.nih.gov/pubmed/26485389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005165
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