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Structure Elucidation of Coxsackievirus A16 in Complex with GPP3 Informs a Systematic Review of Highly Potent Capsid Binders to Enteroviruses

The replication of enterovirus 71 (EV71) and coxsackievirus A16 (CVA16), which are the major cause of hand, foot and mouth disease (HFMD) in children, can be inhibited by the capsid binder GPP3. Here, we present the crystal structure of CVA16 in complex with GPP3, which clarifies the role of the key...

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書誌詳細
出版年:PLoS Pathog
主要な著者: De Colibus, Luigi, Wang, Xiangxi, Tijsma, Aloys, Neyts, Johan, Spyrou, John A. B., Ren, Jingshan, Grimes, Jonathan M., Puerstinger, Gerhard, Leyssen, Pieter, Fry, Elizabeth E., Rao, Zihe, Stuart, David I.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4613828/
https://ncbi.nlm.nih.gov/pubmed/26485389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005165
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