The Capsid Binder Vapendavir and the Novel Protease Inhibitor SG85 Inhibit Enterovirus 71 Replication

Antivirals against enterovirus 71 (EV71) are urgently needed. We demonstrate that the novel enteroviral protease inhibitor (PI) SG85 and capsid binder (CB) vapendavir efficiently inhibit the in vitro replication of 21 EV71 strains/isolates that are representative of the different genogroups A, B, an...

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Bibliografiset tiedot
Julkaisussa:Antimicrob Agents Chemother
Päätekijät: Tijsma, Aloys, Franco, David, Tucker, Simon, Hilgenfeld, Rolf, Froeyen, Mathy, Leyssen, Pieter, Neyts, Johan
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2014
Aiheet:
Antiviral Agents
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249361/
https://ncbi.nlm.nih.gov/pubmed/25199773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03328-14
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