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The Enterovirus 3C Protease Inhibitor SG85 Efficiently Blocks Rhinovirus Replication and Is Not Cross-Resistant with Rupintrivir

The novel enterovirus protease inhibitor (PI) SG85 effectively inhibits the in vitro replication of 14 rhinoviruses representative of species A and B (median 50% effective concentration, 0.04 μM). A low-level SG85-resistant variant was selected that carried amino acid substitutions S127G and T143A i...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Lacroix, Céline, George, Shyla, Leyssen, Pieter, Hilgenfeld, Rolf, Neyts, Johan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538484/
https://ncbi.nlm.nih.gov/pubmed/26055377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00534-15
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