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The Enterovirus 3C Protease Inhibitor SG85 Efficiently Blocks Rhinovirus Replication and Is Not Cross-Resistant with Rupintrivir
The novel enterovirus protease inhibitor (PI) SG85 effectively inhibits the in vitro replication of 14 rhinoviruses representative of species A and B (median 50% effective concentration, 0.04 μM). A low-level SG85-resistant variant was selected that carried amino acid substitutions S127G and T143A i...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Antimicrob Agents Chemother |
|---|---|
| Prif Awduron: | , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
American Society for Microbiology
2015
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4538484/ https://ncbi.nlm.nih.gov/pubmed/26055377 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00534-15 |
| Tagiau: |
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