3C Protease of Enterovirus 68: Structure-Based Design of Michael Acceptor Inhibitors and Their Broad-Spectrum Antiviral Effects against Picornaviruses

We have determined the cleavage specificity and the crystal structure of the 3C protease of enterovirus 68 (EV68 3C(pro)). The protease exhibits a typical chymotrypsin fold with a Cys...His...Glu catalytic triad; its three-dimensional structure is closely related to that of the 3C(pro) of rhinovirus...

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Detalhes bibliográficos
Main Authors: Tan, Jinzhi, George, Shyla, Kusov, Yuri, Perbandt, Markus, Anemüller, Stefan, Mesters, Jeroen R., Norder, Helene, Coutard, Bruno, Lacroix, Céline, Leyssen, Pieter, Neyts, Johan, Hilgenfeld, Rolf
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624371/
https://ncbi.nlm.nih.gov/pubmed/23388726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01123-12
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