Application of a cell-based protease assay for testing inhibitors of picornavirus 3C proteases

Proteolytical cleavage of the picornaviral polyprotein is essential for viral replication. Therefore, viral proteases are attractive targets for anti-viral therapy. Most assays available for testing proteolytical activity of proteases are performed in vitro, using heterologously expressed proteases...

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Detalhes bibliográficos
Publicado no:Antiviral Res
Main Authors: van der Linden, Lonneke, Ulferts, Rachel, Nabuurs, Sander B., Kusov, Yuri, Liu, Hong, George, Shyla, Lacroix, Céline, Goris, Nesya, Lefebvre, David, Lanke, Kjerstin H.W., De Clercq, Kris, Hilgenfeld, Rolf, Neyts, Johan, van Kuppeveld, Frank J.M.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier B.V. 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7113757/
https://ncbi.nlm.nih.gov/pubmed/24393668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2013.12.012
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