Application of a cell-based protease assay for testing inhibitors of picornavirus 3C proteases

Proteolytical cleavage of the picornaviral polyprotein is essential for viral replication. Therefore, viral proteases are attractive targets for anti-viral therapy. Most assays available for testing proteolytical activity of proteases are performed in vitro, using heterologously expressed proteases...

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Publicat a:Antiviral Res
Autors principals: van der Linden, Lonneke, Ulferts, Rachel, Nabuurs, Sander B., Kusov, Yuri, Liu, Hong, George, Shyla, Lacroix, Céline, Goris, Nesya, Lefebvre, David, Lanke, Kjerstin H.W., De Clercq, Kris, Hilgenfeld, Rolf, Neyts, Johan, van Kuppeveld, Frank J.M.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier B.V. 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7113757/
https://ncbi.nlm.nih.gov/pubmed/24393668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2013.12.012
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