Beta-Propiolactone Inactivation of Coxsackievirus A16 Induces Structural Alteration and Surface Modification of Viral Capsids

Beta-propiolactone (BPL) is an inactivating agent that is widely used in the vaccine industry. However, its effects on vaccine protein antigens and its mechanisms of action remain poorly understood. Here we present cryo-electron microscopy (cryo-EM) structures of BPL-treated coxsackievirus A16 (CVA1...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Fan, Chen, Ye, Xiaohua, Ku, Zhiqiang, Kong, Liangliang, Liu, Qingwei, Xu, Cong, Cong, Yao, Huang, Zhong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5375664/
https://ncbi.nlm.nih.gov/pubmed/28148783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00038-17
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