Beta-Propiolactone Inactivation of Coxsackievirus A16 Induces Structural Alteration and Surface Modification of Viral Capsids

Beta-propiolactone (BPL) is an inactivating agent that is widely used in the vaccine industry. However, its effects on vaccine protein antigens and its mechanisms of action remain poorly understood. Here we present cryo-electron microscopy (cryo-EM) structures of BPL-treated coxsackievirus A16 (CVA1...

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Detalles Bibliográficos
Publicado en:J Virol
Autores principales: Fan, Chen, Ye, Xiaohua, Ku, Zhiqiang, Kong, Liangliang, Liu, Qingwei, Xu, Cong, Cong, Yao, Huang, Zhong
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2017
Materias:
Vaccines and Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5375664/
https://ncbi.nlm.nih.gov/pubmed/28148783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00038-17
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