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Beta-Propiolactone Inactivation of Coxsackievirus A16 Induces Structural Alteration and Surface Modification of Viral Capsids

Beta-propiolactone (BPL) is an inactivating agent that is widely used in the vaccine industry. However, its effects on vaccine protein antigens and its mechanisms of action remain poorly understood. Here we present cryo-electron microscopy (cryo-EM) structures of BPL-treated coxsackievirus A16 (CVA1...

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書誌詳細
出版年:J Virol
主要な著者: Fan, Chen, Ye, Xiaohua, Ku, Zhiqiang, Kong, Liangliang, Liu, Qingwei, Xu, Cong, Cong, Yao, Huang, Zhong
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5375664/
https://ncbi.nlm.nih.gov/pubmed/28148783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00038-17
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