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Beta-Propiolactone Inactivation of Coxsackievirus A16 Induces Structural Alteration and Surface Modification of Viral Capsids

Beta-propiolactone (BPL) is an inactivating agent that is widely used in the vaccine industry. However, its effects on vaccine protein antigens and its mechanisms of action remain poorly understood. Here we present cryo-electron microscopy (cryo-EM) structures of BPL-treated coxsackievirus A16 (CVA1...

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Bibliografiske detaljer
Udgivet i:J Virol
Main Authors: Fan, Chen, Ye, Xiaohua, Ku, Zhiqiang, Kong, Liangliang, Liu, Qingwei, Xu, Cong, Cong, Yao, Huang, Zhong
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5375664/
https://ncbi.nlm.nih.gov/pubmed/28148783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00038-17
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